- Michael Oher was drafted 23rd overall by the Baltimore Ravens in the 1st round of the 2009 NFL Draft. The Ravens were scheduled to pick 26th overall, but traded that pick and their 5th round pick to the New England Patriots to move up three spots and draft Oher.
- Many real college football coaches played themselves but at former schools: Phillip Fulmer (was Tennessee head coach, now out of football), Lou Holtz (was South Carolina head coach, now does TV), Houston Nutt (was Arkansas head coach, now Ole Miss head coach), Ed Orgeron (was Ole Miss head coach, now assistant at Tennessee), Nick Saban (was LSU head coach, now Alabama head coach), Tommy Tuberville (was Auburn head coach, now Texas Tech head coach).
- Cameo: [Lawrence Taylor] The movie credits Lawrence Taylor of the New York Giants for creating a shift in offensive football strategy where teams started to choose large heavy players to fill the position of left tackle and protect the "blind side" of right handed quarterbacks.
- No body parts are stored at the University of Tennessee's Neyland Stadium. The university has a "body farm" a few miles away, off Neyland Drive. It is surrounded by barbed wire and accessible only to researchers and law enforcement personnel.
- The Lawrence Taylor hit on Joe Theismann happened November 18, 1985, during a Monday Night Football game between the Giants and Redskins. It was the most gruesome injury even seen on a nationally-televised regular season NFL game. Taylor, who frantically motions for help after the hit, claims that he has never seen replays of it, and never wants to.
- Kathy Bates as Miss Sue introduces herself to Mr. and Mrs. Tuohy as a Democrat. In Primary Colors (1998) Bates received a Best Supporting Actress Oscar nomination for playing Libby Holden, a consultant to a philandering Democratic presidential candidate loosely based on Bill Clinton.
- Both Sandra Bullock and Tim McGraw have strong ties to the South and similarities to the real life Tuohy family. Bullock's father was from Alabama; she was born and raised in Virginia, was a high school cheerleader (like Collins Tuohy), dated a football player and attended college in North Carolina. McGraw was born, raised and attended college in Louisiana and loved playing sports as a kid even though he was unaware at the time that his biological father was a professional baseball player.
- As of the 2009-10 season, former Mississippi basketball superstar Sean Tuohy was entering his ninth season as a broadcaster for the NBA Memphis Grizzlies. As depicted in the movie, Tuohy also has a successful fast food business.
- While Collins Tuohy is shown playing volleyball and as a cheerleader in high school, and a picture of the real life Collins as an Ole Miss cheerleader is shown during the closing credits, Collins also was a state pole vault champion.
- In real life, Oher attended was Briarcrest Christian High School. After reading the script, Briarcrest administrators decided not to allow the school's name to be used. They were particularly concerned about scenes that showed Briarcrest teachers expressing doubt about Oher's learning ability. The filmmakers still used Briarcrest's school color (green).
- Quinton Aaron trained with the Georgia Tech football team in the spring of 2009 to prepare for the role of Michael Oher.
- Julia Roberts was offered the role of Leigh Anne Tuohy before Sandra Bullock.
When Quinton Aaron auditioned for the film, he was working as a security guard between acting gigs. After his audition, he left a card with his contact information, and offered to work as a security guard on the set. - Oher was an experienced football player when he enrolled at Briarcrest. He developed into a premier left tackle, and was heavily recruited by top schools in the Southeastern Conference. Oher was less than pleased by the movie's depiction of him as passive, unskilled big guy who was only barely acquainted with football.
- While the movie shows Collins Tuohy and Michael Oher studying together at home and school. Collins, an A student, rearranged her schedules, and dropped out of several advanced placement classes, to share more classes with Michael and help him graduate.
The 35mm print sent to theatres was titled "Wonderbar". - When Tim McGraw's character teaches Michael the meaning of "The Charge of the Light Brigade", the basketball game on the TV is Georgia Tech at Georgia.
nominated in golden globe 2010